Neuroajankohtaista

Syksy 2023

El Mahdaoui S, Husted SR, Hansen MB, Cobanovic S, Mahler MR, Buhelt S, von Essen MR, Sellebjerg F, Romme Christensen J. Cerebrospinal fluid soluble CD27 is associated with CD8+ T cells, B cells and biomarkers of B cell activity in relapsing-remitting multiple sclerosis - Journal of Neuroimmunology (jni-journal.com) [https://www.jni-journal.com/article/S0165-5728(23)00114-5/fulltext] J Neuroimmunol. 2023 Aug 15;381:578128. doi: 10.1016/j.jneuroim.2023.578128. Epub 2023 Jun 9. PMID: 37321014. Rosenstein I, Axelsson M, Novakova L, Malmeström C, Blennow K, Zetterberg H, Lycke J Intrathecal kappa free light chain synthesis is associated with worse prognosis in relapsing–remitting multiple sclerosis | Journal of Neurology (springer.com) [https://link.springer.com/article/10.1007/s00415-023-11817-9] J Neurol (2023). https://doi.org/10.1007/s00415-023-11817-9 [https://doi.org/10.1007/s00415-023-11817-9] Polvinen E, Matilainen M, Nylund M, Sucksdorff M, Airas LM. TSPO-Detectable Chronic Active Lesions Predict Disease Progression in Multiple Sclerosis - PMC (nih.gov) [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10291892/] Neurol Neuroimmunol Neuroinflamm. 2023 Jun 22;10(5):e200133 Linnerbauer M, Beyer T, Nirschl L, Farrenkopf D, Lößlein L, Vandrey O, Peter A, Tsaktanis T, Kebir H, Laplaud D, Oellinger R, Engleitner T, Alvarez JI, Rad R, Korn T, Hemmer B, Quintana FJ, Rothhammer V. PD-L1 positive astrocytes attenuate inflammatory functions of PD-1 positive microglia in models of autoimmune neuroinflammation - PubMed (nih.gov) [https://pubmed.ncbi.nlm.nih.gov/37689786/]Nat Commun. 2023 Sep 9;14(1):5555. doi: 10.1038/s41467-023-40982-8. PMID: 37689786; PMCID: PMC10492803.

Kesäkuu 2023

Longitudinal stability of progression-related microglial activity during teriflunomide treatment in patients with multiple sclerosis - PubMed (nih.gov) [https://pubmed.ncbi.nlm.nih.gov/37154404/] Lehto J, Nylund M, Matilainen M, Sucksdorff M, Vuorimaa A, Rajander J, Wahlroos S, Hariri P, Airas L. Eur J Neurol. 2023 May 8. Epub ahead of print.   Positron emission tomography with [18 F]-DPA-714 unveils a smoldering component in most multiple sclerosis lesions which drives disease progression - PubMed (nih.gov) [https://pubmed.ncbi.nlm.nih.gov/37039158/] Hamzaoui, M., Garcia, J., Boffa, G., Lazzarotto, A., Absinta, M., Ricigliano, V.A.G., Soulier, T., Tonietto, M., Gervais, P., Bissery, A., Louapre, C., Bottlaender, M., Bodini, B. and Stankoff, B. (2023), Ann Neurol. In vivo characterization of microglia and myelin relation in multiple sclerosis by combined 11C-PBR28 PET and synthetic MRI - PubMed (nih.gov) [https://pubmed.ncbi.nlm.nih.gov/36859627/] Barletta VT, Herranz E, Treaba CA, Mehndiratta A, Ouellette R, Granberg T, Klawiter EC, Ionete C, Sloane JA, Mainero C. J Neurol. 2023 Jun;270(6):3091-3102.  Association of serum neurofilament light with microglial activation in multiple sclerosis - PubMed (nih.gov) [https://pubmed.ncbi.nlm.nih.gov/37130728/] Saraste M, Matilainen M, Vuorimaa A, Laaksonen S, Sucksdorff M, Leppert D, Kuhle J, Airas L. J Neurol Neurosurg Psychiatry. 2023 May 2:jnnp-2023-331051. Epub ahead of print. Katso Aubagion päivitetty valmisteyhteenveto täältä: Aubagio, INN - teriflunomide (europa.eu) [https://www.ema.europa.eu/en/documents/product-information/aubagio-epar-product-information_fi.pdf]

Alkuvuosi 2023

Sequence similarity between SARS-CoV-2 nucleocapsid and multiple sclerosis-associated proteins provides insight into viral neuropathogenesis following infection - PubMed (nih.gov) [https://pubmed.ncbi.nlm.nih.gov/36617594/] Lake CM, Breen JJ. Sci Rep. 2023 Jan 8;13(1):389. doi: 10.1038/s41598-022-27348-8. Ultrastructural Axon-Myelin Unit Alterations in Multiple Sclerosis Correlate with Inflammation - PubMed (nih.gov) [https://pubmed.ncbi.nlm.nih.gov/36565265/]  van den Bosch A, Hümmert S, Steyer A, Ruhwedel T, Hamann J, Smolders J, Nave K-A, Stadelmann C, Kole MHP, Möbius W, Huitinga I. Ann Neurol. 2023 online ahead of print. doi: 10.1002/ana.26585. Serum Glial Fibrillary Acidic Protein Compared With Neurofilament Light Chain as a Biomarker for Disease Progression in Multiple Sclerosis - PubMed (nih.gov) [https://pubmed.ncbi.nlm.nih.gov/36745446/]  Meier S, Willemse EAJ, Schaedelin S, Oechtering J, Lorscheider J, Melie-Garcia L, Cagol A, Barakovic M, Galbusera R, Subramaniam S, Barro C, Abdelhak A, Thebault S, Achtnichts L, Lalive P, Müller S, Pot C, Salmen A, Disanto G, Zecca C, D'Souza M, Orleth A, Khalil M, Buchmann A, Du Pasquier R, Yaldizli Ö, Derfuss T, Berger K, Hermesdorf M, Wiendl H, Piehl F, Battaglini M, Fischer U, Kappos L, Gobbi C, Granziera C, Bridel C, Leppert D, Maleska Maceski A, Benkert P, Kuhle J. JAMA Neurol. 2023 Feb 6. Online ahead of print. doi: 10.1001/jamaneurol.2022.5250.  Proportion and characteristics of secondary progressive multiple sclerosis in five European registries using objective classifiers - PubMed (nih.gov) [https://pubmed.ncbi.nlm.nih.gov/36816812/]  Forsberg L, Spelman T, Klyve P, Manouchehrinia A, Ramanujam R, Mouresan E, Drahota J, Horakova D, Joensen H, Pontieri L, Magyari M, Ellenberger D, Stahmann A, Rodgers J, Witts J, Middleton R, Nicholas R, Bezlyak V, Adlard N, Hach T, Lines C, Vukusic S, Soilu-Hänninen M, van der Walt A, Butzkueven H, Iaffaldano P, Trojano M, Glaser A, Hillert J. Mult Scler J Exp Transl Clin. 2023 Feb 16;9(1):20552173231153557. doi: 10.1177/20552173231153557.

Joulukuu 2022

Longitudinal clinical study of patients with iron rim lesions in multiple sclerosis [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9679801/] Amjad I Altokhis, Aimee M Hibbert, Christopher M Allen, Olivier Mougin, Abdulmajeed Alotaibi, Su-Yin Lim, Cris S Constantinescu, Rasha Abdel-Fahim, Nikos Evangelou Mult Scler. 2022 Dec; 28(14): 2202–2211. Published online 2022 Aug 24. doi: 10.1177/13524585221114750 Osteopontin associates with brain TRM-cell transcriptome and compartmentalization in donors with and without multiple sclerosis: iScience [https://www.cell.com/iscience/fulltext/S2589-0042(22)02058-2] Cheng-Chih Hsiao, Hendrik J. Engelenburg, Aldo Jongejan, Jing Zhu, Baohong Zhang, Michael Mingueneau, Perry D. Moerland, Inge Huitinga, Joost Smolders, Jörg Hamann Published: December 09, 2022, Cell; iScience Immunosuppressive biomaterial-based therapeutic vaccine to treat multiple sclerosis via re-establishing immune tolerance - PMC (nih.gov) [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9718828/] Thanh Loc Nguyen, Youngjin Choi, Jihye Im, Hyunsu Shin, Ngoc Man Phan, Min Kyung Kim, Seung Woo Choi, Jaeyun Kim. Nat Commun. 2022; 13: 7449. A single-cell analysis framework allows for characterization of CSF leukocytes and their tissue of origin in multiple sclerosis | Science Translational Medicine [https://www.science.org/doi/10.1126/scitranslmed.adc9778] Patrick Ostkamp, Marie Deffner, Andreas Schulte-Mecklenbeck, Christian Wünsch, I-Na Lu, Gregory F Wu, Susan Goelz, Philip L De Jager, Tanja Kuhlmann, Catharina C Gross, Luisa Klotz, Gerd Meyer Zu Hörste, Heinz Wiendl, Tilman Schneider-Hohendorf, Nicholas Schwab Sci Transl Med. 2022 Nov 30;14(673):eadc9778. Toward Precision Phenotyping of Multiple Sclerosis [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9427000/] David Pitt, Chih Hung Lo, Susan A. Gauthier, Richard A. Hickman, Erin Longbrake, Laura M. Airas, Yang Mao-Draayer, Claire Riley, Philip Lawrence De Jager, Sarah Wesley, Aaron Boster, Ilir Topalli, Francesca Bagnato, Mohammad Mansoor, Olaf Stuve, Ilya Kister, Daniel Pelletier, Panos Stathopoulos, Ranjan Dutta, Matthew R. Lincoln Neurol Neuroimmunol Neuroinflamm. 2022 Nov; 9(6): e200025.